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Name:  Ruairí Ó hEithir
Location:  Dún Laoghaire, Ireland
Occupation: Deputy Principal of Rathdown School, a secondary day and boarding school for girls.
Interests: History, politics, Irish language, Rwanda, cookery, reading, science fiction, words.

Welcome! Whether family or friend or stranger, I hope you find something here to amuse, entertain or inform. It's rather an eclectic mix which has lain moribund for quite some time but I hope to get it up and running again!

Any suggestions as to additional content should be emailed to me at roheithir AT gmail DOT com. Recipes are especially welcome!

The two most beautiful places in the world IMHO - Rwanda and the Aran Islands.

THE POETRY OF DONALD RUMSFELD
These are extracts from the speeches of Donald Rumsfeld written out as poems and published by Hart Seely in 2003. They have also been set to music (follow this link for more info)


THE UNKNOWN
As we know,
There are known knowns.
There are things we know we know.

We also know
There are known unknowns.
That is to say
We know there are some things
We do not know.

But there are also unknown unknowns,
The ones we don't know
We don't know.


Donald Rumsfeld, Department of Defense news briefing
Feb. 12, 2002

Glass Box
You know, it's the old glass box at the-
At the gas station,
Where you're using those little things
Trying to pick up the prize,
And you can't find it.
It's-

And it's all these arms are going down in there,
And so you keep dropping it
And picking it up again and moving it,
But-

Some of you are probably too young to remember those-
Those glass boxes,
But-

But they used to have them
At all the gas stations
When I was a kid.


Uk pubmed central (ukpmc) requires javascript to function effectively. Either your web browser doesn't support javascript or it is currently turned off. In the latter case, please turn on javascript support in your web browser and reload this page.   feedback ukpmc labs >> home about funders governance contact us europe pubmed central rss feeds journal list grant lookup faq and guides guides ukpmc+ clear search advanced search recent activity  |  clipboard deficient glycosylation of arylsulfatase a in pseudo arylsulfatase-a deficiency. (pmid:1968615) abstract citations bioentities related articles find all citations by this author (default). Or filter your current search ameen m , find all citations by this author (default). Or filter your current search lazzarino da , find all citations by this author (default). Or filter your current search kelly bm , find all citations by this author (default). Or filter your current search gabel ca , find all citations by this author (default). Or filter your current search chang pl department of pediatrics, mcmaster university, ontario, canada. Find all citations in this journal (default). Or filter your current search molecular and cellular biochemistry [1990, 92(2):117-127] type:  journal article, research support, non-u. S. Gov't doi: 10. 1007/bf00218129 abstract highlight terms gene ontology(4) diseases(3) genes/proteins(4) species(1) chemicals(2) deficient arylsulfatase -a activity is diagnostic of a neurodegenerative human lysosomal storage disease , metachromatic leukodystrophy. cheapest viagra viagra without a doctor prescription buy cheap viagra viagra for sale cheap viagra online cheap viagra http://classicmotocrossimages.com/mbs-canadian-pharmacy-viagra-no-prescription-ex/ viagra online buy generic viagra http://floridalighttacklecharters.com/thq-buy-cheap-viagra-canada-di/ Paradoxically, similar enzyme deficiency also occurs in normal individuals, who are known as being pseudo arylsulfatase -a deficient. We showed previously that this phenotype is associated with a structural gene mutation that produces an exceptionally labile enzyme. We now report on the nature and consequence of this mutation. When the mutant arylsulfatase -a is deglycosylated by endoglycosidase h , only one smaller molecular species was generated, instead of the two from the normal enzyme. This is consistent with the loss of one of the two n-linked oligosaccharide side chains known to be present on the wild-type enzyme. Quantitative analysis of mannose and leucine incorporation showed that the mutant enzyme incorporated two- to tenfold less mannose than the normal enzyme on a molar basis. This deficient glycosylation was specific to arylsulfatase -a. Another lysosomal enzyme not affected in this mutation, beta-hexosaminidase , was glycosylated normally in the mutant cells. The remaining single oligosaccharide side chain released from the mutant arylsulfatase -a by pronase digestio. Department of Defense news briefing
Dec. 6, 2001

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